Promethazine Indicators and signs of overdosage with promethazine vary from gentle depression on the central anxious method and cardiovascular system to profound hypotension, respiratory depression, unconsciousness and sudden Demise.
This medication may well make you extra delicate on the Sunshine. Restrict your time and efforts while in the Sunlight. Stay away from tanning booths and sunlamps. Use sunscreen and have on protecting garments when outside. Tell your health practitioner without delay if you receive sunburned or have pores and skin blisters/redness.
Codeine: A review in rats and rabbits documented no teratogenic influence of codeine administered over the period of organogenesis in doses starting from five to one hundred twenty mg/kg. Within the rat, doses on the 120-mg/kg level, in the poisonous range for that adult animal, have been connected to an increase in embryo resorption at enough time of implantation.
When offered concomitantly with promethazine, the dose of barbiturates really should be diminished by not less than one-fifty percent, along with the dose of narcotics ought to be reduced by just one-quarter to 1-fifty percent. Dosage need to be individualized. Abnormal quantities of promethazine HCl relative into a narcotic may possibly produce restlessness and motor hyperactivity inside the client with soreness; these signs or symptoms generally disappear with adequate Charge of the suffering.
The respiratory-depressant results of narcotic analgesics and their potential to elevate cerebrospinal fluid pressure could be markedly exaggerated inside the presence of head personal injury, intracranial lesions or perhaps a pre-current rise in intracranial strain.
Codeine was not mutagenic while in the in vitro bacterial reverse mutation assay or clastogenic inside the in vitro Chinese hamster ovary (CHO) cell chromosomal aberration assay.
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The phosphate salt of codeine happens as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and marginally soluble in Alcoholic beverages. The molecular excess weight is 406.37. Its molecular components is C18H21NO3•H3PO4 • ½ H2O, and it's the following chemical structure.
Consideration ought to be supplied to your discontinuation of promethazine HCl and to the use of other medications if these reactions take place. Respiratory despair, nightmares, delirium, and agitated behavior have also been noted in A few of these clients.
Promethazine is metabolized because of the liver to a range of inactive metabolites such as sulfoxides of promethazine, N-demethylpromethazine along with other glucuronides.
The dosage is predicated on your age, clinical problem, and response to remedy. Cautiously measure the dose using a special measuring machine/spoon. Tend not to make use of a domestic spoon since you may well not get the right dose.
This medication may perhaps cause you to a lot more sensitive to your Solar. Restrict your time inside the sun. Prevent tanning booths and sunlamps. Use sunscreen and don protective outfits when outdoors. Notify your health practitioner instantly if you obtain sunburned or have pores and skin blisters/redness.
This drugs can be Promethazine codeine syrup used for other applications; talk to your overall health care company or pharmacist When you have inquiries.
If this SPL is made up of inactivated NDCs stated from the FDA initiated compliance action, they will be specified therefore.